MitoPlantRedoxV1, Main, Exploration, bibRecord, 000149

Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.

Identifieur interne : 000149 ( Main/Exploration ); précédent : 000148; suivant : 000150

Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.

Auteurs : Vasily V. Ptushenko [Russie] ; Alexei E. Solovchenko ; Andrew Y. Bychkov ; Olga B. Chivkunova ; Andrey V. Golovin ; Olga A. Gorelova ; Tatiana T. Ismagulova ; Leonid V. Kulik ; Elena S. Lobakova ; Alexandr A. Lukyanov ; Rima I. Samoilova ; Pavel N. Scherbakov ; Irina O. Selyakh ; Larisa R. Semenova ; Svetlana G. Vasilieva ; Olga I. Baulina ; Maxim V. Skulachev ; Mikhail P. Kirpichnikov

Source :

Photosynthesis research [ 1573-5079 ] ; 2019.

RBID : pubmed:31302832

Descripteurs français

KwdFr :
- Antioxydants (métabolisme), Cations (MeSH), Chlorella vulgaris (effets des médicaments et des substances chimiques), Chlorella vulgaris (métabolisme), Chlorophylle (métabolisme), Cinétique (MeSH), Complexe protéique du photosystème II (métabolisme), Fluorescence (MeSH), Interactions hydrophobes et hydrophiles (MeSH), Lumière (MeSH), Manganèse (métabolisme), Oxygène (métabolisme), Plastoquinone 9 (analogues et dérivés), Plastoquinone 9 (pharmacologie), Simulation de docking moléculaire (MeSH).
MESH :
- analogues et dérivés : Plastoquinone 9.
- effets des médicaments et des substances chimiques : Chlorella vulgaris.
- métabolisme : Antioxydants, Chlorella vulgaris, Chlorophylle, Complexe protéique du photosystème II, Manganèse, Oxygène.
- pharmacologie : Plastoquinone 9.
- Cations, Cinétique, Fluorescence, Interactions hydrophobes et hydrophiles, Lumière, Simulation de docking moléculaire.

English descriptors

KwdEn :
- Antioxidants (metabolism), Cations (MeSH), Chlorella vulgaris (drug effects), Chlorella vulgaris (metabolism), Chlorophyll (metabolism), Fluorescence (MeSH), Hydrophobic and Hydrophilic Interactions (MeSH), Kinetics (MeSH), Light (MeSH), Manganese (metabolism), Molecular Docking Simulation (MeSH), Oxygen (metabolism), Photosystem II Protein Complex (metabolism), Plastoquinone (analogs & derivatives), Plastoquinone (pharmacology).
MESH :
- chemical , analogs & derivatives : Plastoquinone.
- chemical , metabolism : Antioxidants, Chlorophyll, Manganese, Oxygen, Photosystem II Protein Complex.
- chemical , pharmacology : Plastoquinone.
- chemical : Cations.
- drug effects : Chlorella vulgaris.
- metabolism : Chlorella vulgaris.
- Fluorescence, Hydrophobic and Hydrophilic Interactions, Kinetics, Light, Molecular Docking Simulation.

Abstract

Mitochondria-targeted antioxidants (also known as 'Skulachev Ions' electrophoretically accumulated by mitochondria) exert anti-ageing and ROS-protecting effects well documented in animal and human cells. However, their effects on chloroplast in photosynthetic cells and corresponding mechanisms are scarcely known. For the first time, we describe a dramatic quenching effect of (10-(6-plastoquinonyl)decyl triphenylphosphonium (SkQ1) on chlorophyll fluorescence, apparently mediated by redox interaction of SkQ1 with Mn cluster in Photosystem II (PSII) of chlorophyte microalga Chlorella vulgaris and disabling the oxygen-evolving complex (OEC). Microalgal cells displayed a vigorous uptake of SkQ1 which internal concentration built up to a very high level. Using optical and EPR spectroscopy, as well as electron donors and in silico molecular simulation techniques, we found that SkQ1 molecule can interact with Mn atoms of the OEC in PSII. This stops water splitting giving rise to potent quencher(s), e.g. oxidized reaction centre of PSII. Other components of the photosynthetic apparatus proved to be mostly intact. This effect of the Skulachev ions might help to develop in vivo models of photosynthetic cells with impaired OEC function but essentially intact otherwise. The observed phenomenon suggests that SkQ1 can be applied to study stress-induced damages to OEC in photosynthetic organisms.

DOI: 10.1007/s11120-019-00657-2
PubMed: 31302832

Affiliations:

Russie

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000098
to stream Main, to step Curation: 000098

Le document en format XML

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<author><name sortKey="Ptushenko, Vasily V" sort="Ptushenko, Vasily V" uniqKey="Ptushenko V" first="Vasily V" last="Ptushenko">Vasily V. Ptushenko</name>
<affiliation wicri:level="1"><nlm:affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234. ptush@belozersky.msu.ru.</nlm:affiliation>
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<author><name sortKey="Solovchenko, Alexei E" sort="Solovchenko, Alexei E" uniqKey="Solovchenko A" first="Alexei E" last="Solovchenko">Alexei E. Solovchenko</name>
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<author><name sortKey="Bychkov, Andrew Y" sort="Bychkov, Andrew Y" uniqKey="Bychkov A" first="Andrew Y" last="Bychkov">Andrew Y. Bychkov</name>
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<author><name sortKey="Chivkunova, Olga B" sort="Chivkunova, Olga B" uniqKey="Chivkunova O" first="Olga B" last="Chivkunova">Olga B. Chivkunova</name>
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<author><name sortKey="Golovin, Andrey V" sort="Golovin, Andrey V" uniqKey="Golovin A" first="Andrey V" last="Golovin">Andrey V. Golovin</name>
<affiliation><nlm:affiliation>Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
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<affiliation><nlm:affiliation>Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia, 119991.</nlm:affiliation>
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<author><name sortKey="Gorelova, Olga A" sort="Gorelova, Olga A" uniqKey="Gorelova O" first="Olga A" last="Gorelova">Olga A. Gorelova</name>
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<author><name sortKey="Ismagulova, Tatiana T" sort="Ismagulova, Tatiana T" uniqKey="Ismagulova T" first="Tatiana T" last="Ismagulova">Tatiana T. Ismagulova</name>
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<author><name sortKey="Kulik, Leonid V" sort="Kulik, Leonid V" uniqKey="Kulik L" first="Leonid V" last="Kulik">Leonid V. Kulik</name>
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</affiliation>
</author>
<author><name sortKey="Lobakova, Elena S" sort="Lobakova, Elena S" uniqKey="Lobakova E" first="Elena S" last="Lobakova">Elena S. Lobakova</name>
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<wicri:noCountry code="subField">119234</wicri:noCountry>
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<author><name sortKey="Lukyanov, Alexandr A" sort="Lukyanov, Alexandr A" uniqKey="Lukyanov A" first="Alexandr A" last="Lukyanov">Alexandr A. Lukyanov</name>
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<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
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<author><name sortKey="Samoilova, Rima I" sort="Samoilova, Rima I" uniqKey="Samoilova R" first="Rima I" last="Samoilova">Rima I. Samoilova</name>
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</affiliation>
</author>
<author><name sortKey="Scherbakov, Pavel N" sort="Scherbakov, Pavel N" uniqKey="Scherbakov P" first="Pavel N" last="Scherbakov">Pavel N. Scherbakov</name>
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<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Selyakh, Irina O" sort="Selyakh, Irina O" uniqKey="Selyakh I" first="Irina O" last="Selyakh">Irina O. Selyakh</name>
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<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Semenova, Larisa R" sort="Semenova, Larisa R" uniqKey="Semenova L" first="Larisa R" last="Semenova">Larisa R. Semenova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vasilieva, Svetlana G" sort="Vasilieva, Svetlana G" uniqKey="Vasilieva S" first="Svetlana G" last="Vasilieva">Svetlana G. Vasilieva</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baulina, Olga I" sort="Baulina, Olga I" uniqKey="Baulina O" first="Olga I" last="Baulina">Olga I. Baulina</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Skulachev, Maxim V" sort="Skulachev, Maxim V" uniqKey="Skulachev M" first="Maxim V" last="Skulachev">Maxim V. Skulachev</name>
<affiliation><nlm:affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Institute of Mitoengineering, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kirpichnikov, Mikhail P" sort="Kirpichnikov, Mikhail P" uniqKey="Kirpichnikov M" first="Mikhail P" last="Kirpichnikov">Mikhail P. Kirpichnikov</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.</title>
<author><name sortKey="Ptushenko, Vasily V" sort="Ptushenko, Vasily V" uniqKey="Ptushenko V" first="Vasily V" last="Ptushenko">Vasily V. Ptushenko</name>
<affiliation wicri:level="1"><nlm:affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234. ptush@belozersky.msu.ru.</nlm:affiliation>
<country wicri:rule="url">Russie</country>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>N.M. Emanuel Institute of Biochemical Physics of RAS, Moscow, Russia, 119334. ptush@belozersky.msu.ru.</nlm:affiliation>
<country wicri:rule="url">Russie</country>
</affiliation>
</author>
<author><name sortKey="Solovchenko, Alexei E" sort="Solovchenko, Alexei E" uniqKey="Solovchenko A" first="Alexei E" last="Solovchenko">Alexei E. Solovchenko</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Peoples Friendship University of Russia (RUDN University), Moscow, Russia, 117198.</nlm:affiliation>
<wicri:noCountry code="subField">117198</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bychkov, Andrew Y" sort="Bychkov, Andrew Y" uniqKey="Bychkov A" first="Andrew Y" last="Bychkov">Andrew Y. Bychkov</name>
<affiliation><nlm:affiliation>Faculty of Geology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chivkunova, Olga B" sort="Chivkunova, Olga B" uniqKey="Chivkunova O" first="Olga B" last="Chivkunova">Olga B. Chivkunova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Golovin, Andrey V" sort="Golovin, Andrey V" uniqKey="Golovin A" first="Andrey V" last="Golovin">Andrey V. Golovin</name>
<affiliation><nlm:affiliation>Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia, 119991.</nlm:affiliation>
<wicri:noCountry code="subField">119991</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gorelova, Olga A" sort="Gorelova, Olga A" uniqKey="Gorelova O" first="Olga A" last="Gorelova">Olga A. Gorelova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ismagulova, Tatiana T" sort="Ismagulova, Tatiana T" uniqKey="Ismagulova T" first="Tatiana T" last="Ismagulova">Tatiana T. Ismagulova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kulik, Leonid V" sort="Kulik, Leonid V" uniqKey="Kulik L" first="Leonid V" last="Kulik">Leonid V. Kulik</name>
<affiliation><nlm:affiliation>V.V. Voevodsky Institute of Chemical Kinetics and Combustion of SB RAS, Novosibirsk, Russia, 630090.</nlm:affiliation>
<wicri:noCountry code="subField">630090</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Novosibirsk State University, Pirogova Street 2, Novosibirsk, Russia, 630090.</nlm:affiliation>
<wicri:noCountry code="subField">630090</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lobakova, Elena S" sort="Lobakova, Elena S" uniqKey="Lobakova E" first="Elena S" last="Lobakova">Elena S. Lobakova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lukyanov, Alexandr A" sort="Lukyanov, Alexandr A" uniqKey="Lukyanov A" first="Alexandr A" last="Lukyanov">Alexandr A. Lukyanov</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Samoilova, Rima I" sort="Samoilova, Rima I" uniqKey="Samoilova R" first="Rima I" last="Samoilova">Rima I. Samoilova</name>
<affiliation><nlm:affiliation>V.V. Voevodsky Institute of Chemical Kinetics and Combustion of SB RAS, Novosibirsk, Russia, 630090.</nlm:affiliation>
<wicri:noCountry code="subField">630090</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Scherbakov, Pavel N" sort="Scherbakov, Pavel N" uniqKey="Scherbakov P" first="Pavel N" last="Scherbakov">Pavel N. Scherbakov</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Selyakh, Irina O" sort="Selyakh, Irina O" uniqKey="Selyakh I" first="Irina O" last="Selyakh">Irina O. Selyakh</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Semenova, Larisa R" sort="Semenova, Larisa R" uniqKey="Semenova L" first="Larisa R" last="Semenova">Larisa R. Semenova</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vasilieva, Svetlana G" sort="Vasilieva, Svetlana G" uniqKey="Vasilieva S" first="Svetlana G" last="Vasilieva">Svetlana G. Vasilieva</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baulina, Olga I" sort="Baulina, Olga I" uniqKey="Baulina O" first="Olga I" last="Baulina">Olga I. Baulina</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Skulachev, Maxim V" sort="Skulachev, Maxim V" uniqKey="Skulachev M" first="Maxim V" last="Skulachev">Maxim V. Skulachev</name>
<affiliation><nlm:affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
<affiliation><nlm:affiliation>Institute of Mitoengineering, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kirpichnikov, Mikhail P" sort="Kirpichnikov, Mikhail P" uniqKey="Kirpichnikov M" first="Mikhail P" last="Kirpichnikov">Mikhail P. Kirpichnikov</name>
<affiliation><nlm:affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</nlm:affiliation>
<wicri:noCountry code="subField">119234</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Photosynthesis research</title>
<idno type="eISSN">1573-5079</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antioxidants (metabolism)</term>
<term>Cations (MeSH)</term>
<term>Chlorella vulgaris (drug effects)</term>
<term>Chlorella vulgaris (metabolism)</term>
<term>Chlorophyll (metabolism)</term>
<term>Fluorescence (MeSH)</term>
<term>Hydrophobic and Hydrophilic Interactions (MeSH)</term>
<term>Kinetics (MeSH)</term>
<term>Light (MeSH)</term>
<term>Manganese (metabolism)</term>
<term>Molecular Docking Simulation (MeSH)</term>
<term>Oxygen (metabolism)</term>
<term>Photosystem II Protein Complex (metabolism)</term>
<term>Plastoquinone (analogs & derivatives)</term>
<term>Plastoquinone (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antioxydants (métabolisme)</term>
<term>Cations (MeSH)</term>
<term>Chlorella vulgaris (effets des médicaments et des substances chimiques)</term>
<term>Chlorella vulgaris (métabolisme)</term>
<term>Chlorophylle (métabolisme)</term>
<term>Cinétique (MeSH)</term>
<term>Complexe protéique du photosystème II (métabolisme)</term>
<term>Fluorescence (MeSH)</term>
<term>Interactions hydrophobes et hydrophiles (MeSH)</term>
<term>Lumière (MeSH)</term>
<term>Manganèse (métabolisme)</term>
<term>Oxygène (métabolisme)</term>
<term>Plastoquinone 9 (analogues et dérivés)</term>
<term>Plastoquinone 9 (pharmacologie)</term>
<term>Simulation de docking moléculaire (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Plastoquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antioxidants</term>
<term>Chlorophyll</term>
<term>Manganese</term>
<term>Oxygen</term>
<term>Photosystem II Protein Complex</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Plastoquinone</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cations</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Plastoquinone 9</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Chlorella vulgaris</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Chlorella vulgaris</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chlorella vulgaris</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antioxydants</term>
<term>Chlorella vulgaris</term>
<term>Chlorophylle</term>
<term>Complexe protéique du photosystème II</term>
<term>Manganèse</term>
<term>Oxygène</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Plastoquinone 9</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Fluorescence</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Kinetics</term>
<term>Light</term>
<term>Molecular Docking Simulation</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Cations</term>
<term>Cinétique</term>
<term>Fluorescence</term>
<term>Interactions hydrophobes et hydrophiles</term>
<term>Lumière</term>
<term>Simulation de docking moléculaire</term>
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<front><div type="abstract" xml:lang="en">Mitochondria-targeted antioxidants (also known as 'Skulachev Ions' electrophoretically accumulated by mitochondria) exert anti-ageing and ROS-protecting effects well documented in animal and human cells. However, their effects on chloroplast in photosynthetic cells and corresponding mechanisms are scarcely known. For the first time, we describe a dramatic quenching effect of (10-(6-plastoquinonyl)decyl triphenylphosphonium (SkQ1) on chlorophyll fluorescence, apparently mediated by redox interaction of SkQ1 with Mn cluster in Photosystem II (PSII) of chlorophyte microalga Chlorella vulgaris and disabling the oxygen-evolving complex (OEC). Microalgal cells displayed a vigorous uptake of SkQ1 which internal concentration built up to a very high level. Using optical and EPR spectroscopy, as well as electron donors and in silico molecular simulation techniques, we found that SkQ1 molecule can interact with Mn atoms of the OEC in PSII. This stops water splitting giving rise to potent quencher(s), e.g. oxidized reaction centre of PSII. Other components of the photosynthetic apparatus proved to be mostly intact. This effect of the Skulachev ions might help to develop in vivo models of photosynthetic cells with impaired OEC function but essentially intact otherwise. The observed phenomenon suggests that SkQ1 can be applied to study stress-induced damages to OEC in photosynthetic organisms.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31302832</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-5079</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>142</Volume>
<Issue>2</Issue>
<PubDate><Year>2019</Year>
<Month>Nov</Month>
</PubDate>
</JournalIssue>
<Title>Photosynthesis research</Title>
<ISOAbbreviation>Photosynth Res</ISOAbbreviation>
</Journal>
<ArticleTitle>Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.</ArticleTitle>
<Pagination><MedlinePgn>229-240</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s11120-019-00657-2</ELocationID>
<Abstract><AbstractText>Mitochondria-targeted antioxidants (also known as 'Skulachev Ions' electrophoretically accumulated by mitochondria) exert anti-ageing and ROS-protecting effects well documented in animal and human cells. However, their effects on chloroplast in photosynthetic cells and corresponding mechanisms are scarcely known. For the first time, we describe a dramatic quenching effect of (10-(6-plastoquinonyl)decyl triphenylphosphonium (SkQ1) on chlorophyll fluorescence, apparently mediated by redox interaction of SkQ1 with Mn cluster in Photosystem II (PSII) of chlorophyte microalga Chlorella vulgaris and disabling the oxygen-evolving complex (OEC). Microalgal cells displayed a vigorous uptake of SkQ1 which internal concentration built up to a very high level. Using optical and EPR spectroscopy, as well as electron donors and in silico molecular simulation techniques, we found that SkQ1 molecule can interact with Mn atoms of the OEC in PSII. This stops water splitting giving rise to potent quencher(s), e.g. oxidized reaction centre of PSII. Other components of the photosynthetic apparatus proved to be mostly intact. This effect of the Skulachev ions might help to develop in vivo models of photosynthetic cells with impaired OEC function but essentially intact otherwise. The observed phenomenon suggests that SkQ1 can be applied to study stress-induced damages to OEC in photosynthetic organisms.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ptushenko</LastName>
<ForeName>Vasily V</ForeName>
<Initials>VV</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0003-1268-4414</Identifier>
<AffiliationInfo><Affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234. ptush@belozersky.msu.ru.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>N.M. Emanuel Institute of Biochemical Physics of RAS, Moscow, Russia, 119334. ptush@belozersky.msu.ru.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Solovchenko</LastName>
<ForeName>Alexei E</ForeName>
<Initials>AE</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Peoples Friendship University of Russia (RUDN University), Moscow, Russia, 117198.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bychkov</LastName>
<ForeName>Andrew Y</ForeName>
<Initials>AY</Initials>
<AffiliationInfo><Affiliation>Faculty of Geology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chivkunova</LastName>
<ForeName>Olga B</ForeName>
<Initials>OB</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Golovin</LastName>
<ForeName>Andrey V</ForeName>
<Initials>AV</Initials>
<AffiliationInfo><Affiliation>Faculty of Bioengineering and Bioinformatics, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia, 119991.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gorelova</LastName>
<ForeName>Olga A</ForeName>
<Initials>OA</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ismagulova</LastName>
<ForeName>Tatiana T</ForeName>
<Initials>TT</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kulik</LastName>
<ForeName>Leonid V</ForeName>
<Initials>LV</Initials>
<AffiliationInfo><Affiliation>V.V. Voevodsky Institute of Chemical Kinetics and Combustion of SB RAS, Novosibirsk, Russia, 630090.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Novosibirsk State University, Pirogova Street 2, Novosibirsk, Russia, 630090.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lobakova</LastName>
<ForeName>Elena S</ForeName>
<Initials>ES</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lukyanov</LastName>
<ForeName>Alexandr A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Samoilova</LastName>
<ForeName>Rima I</ForeName>
<Initials>RI</Initials>
<AffiliationInfo><Affiliation>V.V. Voevodsky Institute of Chemical Kinetics and Combustion of SB RAS, Novosibirsk, Russia, 630090.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scherbakov</LastName>
<ForeName>Pavel N</ForeName>
<Initials>PN</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Selyakh</LastName>
<ForeName>Irina O</ForeName>
<Initials>IO</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Semenova</LastName>
<ForeName>Larisa R</ForeName>
<Initials>LR</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vasilieva</LastName>
<ForeName>Svetlana G</ForeName>
<Initials>SG</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baulina</LastName>
<ForeName>Olga I</ForeName>
<Initials>OI</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Skulachev</LastName>
<ForeName>Maxim V</ForeName>
<Initials>MV</Initials>
<AffiliationInfo><Affiliation>A.N. Belozersky Institute of Physical-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Mitoengineering, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kirpichnikov</LastName>
<ForeName>Mikhail P</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia, 119234.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>19-04-00509</GrantID>
<Agency>Russian Foundation for Basic Research</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>RUDN University Program 5-100</GrantID>
<Agency>Peoples Friendship University of Russia (RUDN University)</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>07</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Photosynth Res</MedlineTA>
<NlmUniqueID>100954728</NlmUniqueID>
<ISSNLinking>0166-8595</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C532038">10-(6'-plastoquinonyl)decyltriphenylphosphonium</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000975">Antioxidants</NameOfSubstance>
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<NameOfSubstance UI="D002412">Cations</NameOfSubstance>
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<NameOfSubstance UI="D045332">Photosystem II Protein Complex</NameOfSubstance>
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<Chemical><RegistryNumber>1406-65-1</RegistryNumber>
<NameOfSubstance UI="D002734">Chlorophyll</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>42Z2K6ZL8P</RegistryNumber>
<NameOfSubstance UI="D008345">Manganese</NameOfSubstance>
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<Chemical><RegistryNumber>OAC30J69CN</RegistryNumber>
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<Chemical><RegistryNumber>S88TT14065</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000975" MajorTopicYN="N">Antioxidants</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002412" MajorTopicYN="N">Cations</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D048408" MajorTopicYN="N">Chlorella vulgaris</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002734" MajorTopicYN="N">Chlorophyll</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005453" MajorTopicYN="N">Fluorescence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057927" MajorTopicYN="N">Hydrophobic and Hydrophilic Interactions</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008027" MajorTopicYN="N">Light</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008345" MajorTopicYN="N">Manganese</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D062105" MajorTopicYN="N">Molecular Docking Simulation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045332" MajorTopicYN="N">Photosystem II Protein Complex</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010971" MajorTopicYN="N">Plastoquinone</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chlorophyll fluorescence quenching</Keyword>
<Keyword MajorTopicYN="N">Oxygen-evolving complex</Keyword>
<Keyword MajorTopicYN="N">P680 + accumulation</Keyword>
<Keyword MajorTopicYN="N">Photosystem II</Keyword>
<Keyword MajorTopicYN="N">Skulachev ions</Keyword>
<Keyword MajorTopicYN="N">YZ</Keyword>
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<affiliations><list><country><li>Russie</li>
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<name sortKey="Bychkov, Andrew Y" sort="Bychkov, Andrew Y" uniqKey="Bychkov A" first="Andrew Y" last="Bychkov">Andrew Y. Bychkov</name>
<name sortKey="Chivkunova, Olga B" sort="Chivkunova, Olga B" uniqKey="Chivkunova O" first="Olga B" last="Chivkunova">Olga B. Chivkunova</name>
<name sortKey="Golovin, Andrey V" sort="Golovin, Andrey V" uniqKey="Golovin A" first="Andrey V" last="Golovin">Andrey V. Golovin</name>
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<name sortKey="Ismagulova, Tatiana T" sort="Ismagulova, Tatiana T" uniqKey="Ismagulova T" first="Tatiana T" last="Ismagulova">Tatiana T. Ismagulova</name>
<name sortKey="Kirpichnikov, Mikhail P" sort="Kirpichnikov, Mikhail P" uniqKey="Kirpichnikov M" first="Mikhail P" last="Kirpichnikov">Mikhail P. Kirpichnikov</name>
<name sortKey="Kulik, Leonid V" sort="Kulik, Leonid V" uniqKey="Kulik L" first="Leonid V" last="Kulik">Leonid V. Kulik</name>
<name sortKey="Lobakova, Elena S" sort="Lobakova, Elena S" uniqKey="Lobakova E" first="Elena S" last="Lobakova">Elena S. Lobakova</name>
<name sortKey="Lukyanov, Alexandr A" sort="Lukyanov, Alexandr A" uniqKey="Lukyanov A" first="Alexandr A" last="Lukyanov">Alexandr A. Lukyanov</name>
<name sortKey="Samoilova, Rima I" sort="Samoilova, Rima I" uniqKey="Samoilova R" first="Rima I" last="Samoilova">Rima I. Samoilova</name>
<name sortKey="Scherbakov, Pavel N" sort="Scherbakov, Pavel N" uniqKey="Scherbakov P" first="Pavel N" last="Scherbakov">Pavel N. Scherbakov</name>
<name sortKey="Selyakh, Irina O" sort="Selyakh, Irina O" uniqKey="Selyakh I" first="Irina O" last="Selyakh">Irina O. Selyakh</name>
<name sortKey="Semenova, Larisa R" sort="Semenova, Larisa R" uniqKey="Semenova L" first="Larisa R" last="Semenova">Larisa R. Semenova</name>
<name sortKey="Skulachev, Maxim V" sort="Skulachev, Maxim V" uniqKey="Skulachev M" first="Maxim V" last="Skulachev">Maxim V. Skulachev</name>
<name sortKey="Solovchenko, Alexei E" sort="Solovchenko, Alexei E" uniqKey="Solovchenko A" first="Alexei E" last="Solovchenko">Alexei E. Solovchenko</name>
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<country name="Russie"><noRegion><name sortKey="Ptushenko, Vasily V" sort="Ptushenko, Vasily V" uniqKey="Ptushenko V" first="Vasily V" last="Ptushenko">Vasily V. Ptushenko</name>
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   |texte=   Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.
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	Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les mitochondries dans l'oxydoréduction chez les plantes

Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.

Cationic penetrating antioxidants switch off Mn cluster of photosystem II in situ.

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